While the renal system is often most acutely affected, eventually the cardiac, pulmonary GI and CNS systems may be as well.Ġ-24 hours: Increased thirst and urination, hypercalcemia, hyperphosphatemiaġ2-48 hours: Anorexia, vomiting, weakness, lethargy, melena (black stool with digested blood)ģ-5 days: Depression, frank bloody diarrhea, hematuria, prominent bradycardia, death Signs typically begin 12-24 hours after ingestion and may be non-specific at the onset. Human vitamin D3 supplements taken at high enough doses are also toxic via this same mechanism. Even though this is a vitamin, it is toxic to dogs, cats, and children as well as rodents. This can progress to life-threatening disease. Cholecalciferol, or activated vitamin D3, causes a life-threateningly high calcium and phosphorus level in the body, resulting in severe, acute kidney failure, cardiovascular abnormalities, and tissue mineralization.
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